|
|
5,6,7,8-tetrahydromethanopterin + formylmethanofuran + H+ <=> 5-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran
|
2.3.1.101
formylmethanofuran---tetrahydromethanopterin N-formyltransferase
|
–
|
BMK
|
|
BRENDA:
BR43965
KEGG:
R03390
MetaCyc:
2.3.1.101-RXN
|
|
|
|
coenzyme_M + 5-Methyl-5,6,7,8-tetrahydromethanopterin + Na+ <=> methyl-CoM + 5,6,7,8-tetrahydromethanopterin + Na+
|
2.1.1.86
tetrahydromethanopterin S-methyltransferase
|
–
|
BM
|
|
BRENDA:
BR47637
MetaCyc:
2.1.1.86-RXN
|
|
|
|
5,6,7,8-tetrahydromethanopterin + L-glutamate + ATP <=> H+ + tetrahydrosarcinapterin + ADP + phosphate
|
6.3.2.33
tetrahydrosarcinapterin synthase
|
–
|
BK
|
|
BRENDA:
BR49212
KEGG:
R09594
MetaCyc:
RXN-11103
|
|
|
|
5,6,7,8-tetrahydromethanopterin + NADP+ <=> 7,8-dihydromethanopterin + NADPH + H+
|
1.5.1.47
dihydromethanopterin reductase [NAD(P)+]
|
–
|
BK
|
|
BRENDA:
BR50394
KEGG:
R03388
MetaCyc:
RXN-10029
|
|
|
|
5,6,7,8-tetrahydromethanopterin + NAD+ <=> 7,8-dihydromethanopterin + NADH + H+
|
1.5.1.47
dihydromethanopterin reductase [NAD(P)+]
|
–
|
|
|
BRENDA:
BR50394-a
KEGG:
R10332
MetaCyc:
RXN-10029_WOP
|
|
|
|
5,10-methylenetetrahydromethanopterin + H2O <=> formaldehyde + 5,6,7,8-tetrahydromethanopterin
|
4.2.1.147
5,6,7,8-tetrahydromethanopterin hydro-lyase
|
–
|
BMK
|
|
BRENDA:
BR51000
KEGG:
R08058
MetaCyc:
RXN-2882
SABIO-RK:
12954
|
|
|
|
5-Methyl-5,6,7,8-tetrahydromethanopterin + coenzyme_M <=> 5,6,7,8-tetrahydromethanopterin + methyl-CoM
|
2.1.1.86
tetrahydromethanopterin S-methyltransferase
|
–
|
|
|
BRENDA:
BS356061
|
|
|
|
5,6,7,8-tetrahydromethanopterin + acceptor <=> 7,8-dihydromethanopterin + reduced_acceptor
|
1.5.99.15
dihydromethanopterin reductase (acceptor)
|
–
|
MK
|
|
KEGG:
R10802
MetaCyc:
RXN-15555
|
|
|
|
5,10-methylenetetrahydromethanopterin + glycine + H2O <=> 5,6,7,8-tetrahydromethanopterin + L-serine
|
2.1.2
2.1.2.1
glycine hydroxymethyltransferase
|
–
–
|
K
|
|
KEGG:
R09099
MetaCyc:
THMPT-SER-RXN
|
|
|
|
acetyl-CoA + 5,6,7,8-tetrahydromethanopterin <=> CoA + 5-Methyl-5,6,7,8-tetrahydromethanopterin + CO
|
not assigned
|
–
|
K
|
|
KEGG:
R09096
|
|
|
|
5,10-methylenetetrahydromethanopterin + 2-oxoisovalerate + H2O <=> ketopantoate + 5,6,7,8-tetrahydromethanopterin
|
2.1.2.11
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
–
|
M
|
|
MetaCyc:
RXN-15635
|
|
|
|
5,6,7,8-tetrahydromethanopterin + a_[methyl-Co(III)_corrinoid_Fe-S_protein] <=> 5-Methyl-5,6,7,8-tetrahydromethanopterin + [Co(I)_corrinoid_Fe-S_protein] + H+
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
M
|
|
MetaCyc:
RXN-17760
|
|
|
|
5-formyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H+ + formate + 5,6,7,8-tetrahydromethanopterin
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-2884
|
|
|
|
N-Furfurylformamide + 5,6,7,8-tetrahydromethanopterin <=> 2-(aminomethyl)furane + 5-formyl-5,6,7,8-tetrahydromethanopterin
|
2.3.1.101
formylmethanofuran---tetrahydromethanopterin N-formyltransferase
|
–
|
|
|
BRENDA:
BS320248
|
|
|
|
7,8-dihydromethanopterin + reduced_ferredoxin <=> 5,6,7,8-tetrahydromethanopterin + Ferredoxin
|
1.5.99.15
dihydromethanopterin reductase (acceptor)
|
–
|
|
|
BRENDA:
BS440124
|
|
|
|
5,6,7,8-tetrahydromethanopterin + methyl-cob(III)alamin <=> 5-Methyl-5,6,7,8-tetrahydromethanopterin + cob(III)alamin
|
2.1.1.86
tetrahydromethanopterin S-methyltransferase
|
–
|
|
|
BRENDA:
BS433305
|
|
|
|
CH3-CO-S-CoA + H+ + 5,6,7,8-tetrahydromethanopterin <=> 5-Methyl-5,6,7,8-tetrahydromethanopterin + CO + CoA
|
2.3.1.169
CO-methylating acetyl-CoA synthase
|
–
|
|
|
BRENDA:
BS359571
|
|
|
|
7,8-dihydromethanopterin + reduced_dithiothreitol <=> 5,6,7,8-tetrahydromethanopterin + oxidized_dithiothreitol
|
1.5.99.15
dihydromethanopterin reductase (acceptor)
|
–
|
|
|
BRENDA:
BS428111
|
|
|
|
GTP + 5,6,7,8-tetrahydromethanopterin + L-glutamate <=> GDP + phosphate + tetrahydrosarcinapterin
|
6.3.2.33
tetrahydrosarcinapterin synthase
|
–
|
|
|
BRENDA:
BR49213
|
|
|
|
7,8-dihydromethanopterin + FMNH2 <=> 5,6,7,8-tetrahydromethanopterin + FMN
|
1.5.99.15
dihydromethanopterin reductase (acceptor)
|
–
|
|
|
BRENDA:
BS440123
|
|
|
|
5,6,7,8-tetrahydromethanopterin + oxidized_acceptor <=> 7,8-dihydromethanopterin + reduced_acceptor
|
1.5.99.15
dihydromethanopterin reductase (acceptor)
|
–
|
|
|
BRENDA:
BR51105
|
|
|
|
formaldehyde + 5,6,7,8-tetrahydromethanopterin <=> H2 + 5,10-methylenetetrahydromethanopterin
|
not assigned
|
–
|
|
|
SABIO-RK:
13044
|
|